Watch San Francisco 49ers vs Indianapolis Colts on Sunday, November 1, 2009 at the Lucas Oil Stadium in Indianapolis, IN. Alex Smith is starting at QB for the 49ers. Won't matter. Peyton Manning and the Colts will jump out to an early lead and the 49ers will be out of it so whatever Smith does really won't matter.
Prediction: 49ers 17 Colts 34
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